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Article

A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data.

Genes - 6 Jan 2022

Hahn Georg, Prokopenko Dmitry, Lutz Sharon M, Mullin Kristina, Tanzi Rudolph E, Cho Michael H, Silverman Edwin K, Lange Christoph, On The Behalf Of The Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium

Abstract excerpt

Polygenic risk scores are a popular means to predict the disease risk or disease susceptibility of an individual based on its genotype information. When adding other important epidemiological covariates such as age or sex, we speak of an integrated risk model. Methodological advances for fitting more accurate integrated risk models are of immediate importance to improve the precision of risk prediction, thereby...

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Identifiers

PMID: 35052450
DOI: 10.3390/genes13010112
PMCID: PMC8775060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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