Polygenic scores via penalized regression on summary statistics.

Abstract excerpt

Polygenic scores (PGS) summarize the genetic contribution of a person's genotype to a disease or phenotype. They can be used to group participants into different risk categories for diseases, and are also used as covariates in epidemiological analyses. A number of possible ways of calculating PGS have been proposed, and recently there is much interest in methods that incorporate information available in published...

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• Case-Control Studies
• Computer Simulation
• Databases, Genetic
• Models, Genetic
• Multifactorial Inheritance