Article
Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism.
PloS one - 1 Jan 2022
Kirk L Madison, Waits Charlotte Mae K, Bashore Alexander C, Dosso Beverly, Meyers Allison K, Renaldo Antonio C, DePalma Thomas J, Simms Kelli N, Hauser Nathaniel, Chuang Key Chia-Chi, McCall Charles E, Parks John S, Sergeant Susan, Langefeld Carl D, Skardal Aleksander, Rahbar Elaheh
Abstract excerpt
The Modern Western Diet has been associated with the rise in metabolic and inflammatory diseases, including obesity, diabetes, and cardiovascular disease. This has been attributed, in part, to the increase in dietary omega-6 polyunsaturated fatty acid (PUFA) consumption, specifically linoleic acid (LA), arachidonic acid (ARA), and their subsequent metabolism to pro-inflammatory metabolites which may be driving...
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