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Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score

12 Jun 2023

Abstract excerpt

Abstract Background Polygenic risk score (PRS) analysis is used to predict disease risk. Although PRS has been shown to have great potential in improving clinical care, PRS accuracy assessment has been mainly focused on European ancestry. This study aimed to develop an accurate genetic risk score for knee osteoarthritis (OA) using a multi-population PRS and leveraging a multi-trait PRS in the Japanese population....

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Share to Genetic Associations and Epidemiology
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PMID: 37309008
DOI: 10.1186/s13075-023-03082-y

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