Article
Measurable residual disease, FLT3-ITD mutation, and disease status have independent prognostic influence on outcome of allogeneic stem cell transplantation in NPM1-mutated acute myeloid leukemia.
Cancer medicine - 1 Feb 2022
Al Hamed Rama, Labopin Myriam, Daguindau Etienne, Niittyvuopio Riitta, Huynh Anne, Socié Gerard, Srour Micha, Henri Bourhis Jean, Kröger Nicolaus, Tholouli Eleni, Choi Goda, Poiré Xavier, Martin Hans, Rubio Marie-Thérèse, Jindra Pavel, Blaise Didier, Beelen Dietrich, Labussière-Wallet Hélène, Nagler Arnon, Bazarbachi Ali, Mohty Mohamad
Abstract excerpt
Nucleophosmin-1 (NPM1) mutations in acute myeloid leukemia (AML) confer a survival advantage in the absence of FLT3-internal tandem duplication (FLT3-ITD). Here, we investigated the main predictors of outcome after allogeneic hematopoietic stem cell transplantation (allo-HCT). We identified 1572 adult (age ≥ 18 year) patients with NPM1-mutated AML in first complete remission (CR1:78%) or second complete remission...
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