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Article

Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress.

Science signaling - 11 Jun 2024

Chua Vivian, Lopez-Anton Melisa, Mizue Terai, Ryota Tanaka, Baqai Usman, Purwin Timothy J, Haj Jelan I, Waltrich Francis J, Trachtenberg Isabella, Luo Kristine, Tudi Rohith, Jeon Angela, Han Anna, Chervoneva Inna, Davies Michael A, Aguirre-Ghiso Julio A, Sato Takami, Aplin Andrew E

Abstract excerpt

Uveal melanoma (UM) is the deadliest form of eye cancer in adults. Inactivating mutations and/or loss of expression of the gene encoding BRCA1-associated protein 1 (BAP1) in UM tumors are associated with an increased risk of metastasis. To investigate the mechanisms underlying this risk, we explored the functional consequences of BAP1 deficiency. UM cell lines expressing mutant BAP1 grew more slowly than those...

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Share to Cell Proliferation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Stress, Physiological

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

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Source

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Identifiers

PMID: 38861613
DOI: 10.1126/scisignal.adn8376
PMCID: PMC11328427

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