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Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer

8 Aug 2022

Abstract excerpt

Recent studies have proposed that pyruvate dehydrogenase E1 component subunit alpha (PDHA1), a cuproptosis-key gene, is crucial to the glucose metabolism reprogram of tumor cells. However, the functional roles and regulated mechanisms of PDHA1 in multiple cancers are largely unknown. The Cancer Genome Atlas (TCGA), GEPIA2, and cBioPortal databases were utilized to elucidate the function of PDHA1 in 33 tumor...

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Identifiers

PMID: 36003495
DOI: 10.3389/fphar.2022.947372

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