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Article

The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.

Pigment cell & melanoma research - 1 Jan 2022

Chua Vivian, Han Anna, Bechtel Nelisa, Purwin Timothy J, Hunter Emily, Liao Connie, Harbour J William, Aplin Andrew E

Abstract excerpt

Metastatic uveal melanoma (UM) responds poorly to targeted therapies and immune checkpoint inhibitors. Loss of BRCA1-associated protein 1 (BAP1) via inactivating mutations in the BAP1 gene is associated with UM progression. Thus, molecular alterations caused by BAP1 dysfunction may be novel therapeutic targets for metastatic UM. Here, we found that phosphorylation of AMP-dependent kinase (AMPK) was elevated in...

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Share to Acetyl-CoA Carboxylase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34347929
DOI: 10.1111/pcmr.13007

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