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Article

Phenotype Shifting in Astrocytes Account for Benefits of Intra-Arterial Selective Cooling Infusion in Hypertensive Rats of Ischemic Stroke.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jan 2022

Wang Luling, Wu Longfei, Duan Yunxia, Xu Shuaili, Yang Yuyao, Yin Jidong, Lang Ye, Gao Zongen, Wu Chuanjie, Lv Zaigang, Shi Jingfei, Wu Di, Ji Xunming

Abstract excerpt

The translational failure of neuroprotective therapies in stroke may be influenced by the mismatch of existing comorbidities between animal models and patients. Previous studies found that single-target neuroprotective agents reduced infarction in Sprague-Dawley but not in spontaneously hypertensive rats. It is of great interest to explore whether multi-target neuroprotectants and stroke models with comorbidities...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35044645
DOI: 10.1007/s13311-022-01186-y
PMCID: PMC9130426

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