Article
Smooth muscle cell phenotypic switching in stroke.
Translational stroke research - 1 Jun 2014
Poittevin Marine, Lozeron Pierre, Hilal Rose, Levy Bernard I, Merkulova-Rainon Tatiana, Kubis Nathalie
Abstract excerpt
Disruption of cerebral blood flow after stroke induces cerebral tissue injury through multiple mechanisms that are not yet fully understood. Smooth muscle cells (SMCs) in blood vessel walls play a key role in cerebral blood flow control. Cerebral ischemia triggers these cells to switch to a phenotype that will be either detrimental or beneficial to brain repair. Moreover, SMC can be primarily affected genetically...
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