Article
Spontaneously hypertensive rats display reduced microglial activation in response to ischemic stroke and lipopolysaccharide.
Journal of neuroinflammation - 30 May 2012
De Geyter Deborah, Stoop Wendy, Zgavc Tine, Sarre Sophie, Michotte Yvette, De Keyser Jacques, Kooijman Ron
Abstract excerpt
BACKGROUND: For successful translation to clinical stroke studies, the Stroke Therapy Academic Industry Round Table criteria have been proposed. Two important criteria are testing of therapeutic interventions in conscious animals and the presence of a co-morbidity factor. We chose to work with hypertensive rats since hypertension is an important modifiable risk factor for stroke and influences the clinical...
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