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Article

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians.

Diabetes - 1 Aug 2017

Piaggi Paolo, Masindova Ivica, Muller Yunhua L, Mercader Josep, Wiessner Gregory B, Chen Peng, Kobes Sayuko, Hsueh Wen-Chi, Mongalo Milliejoan, Knowler William C, Krakoff Jonathan, Hanson Robert L, Bogardus Clifton, Baier Leslie J

Abstract excerpt

Pima Indians living in Arizona have a high prevalence of obesity, and we have previously shown that a relatively lower energy expenditure (EE) predicts weight and fat mass gain in this population. EE is a familial trait (heritability = 0.52); therefore, in the current study, we aimed to identify genetic variants that affect EE and thereby influence BMI and body fatness in Pima Indians. Genotypic data from 491,265...

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Identifiers

PMID: 28476931
DOI: 10.2337/db16-1565
PMCID: PMC5521859

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RGS7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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