Article
Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.
European journal of human genetics : EJHG - 1 Oct 2022
Muller Yunhua L, Saporito Michael, Day Samantha, Bandesh Khushdeep, Koroglu Cigdem, Kobes Sayuko, Knowler William C, Hanson Robert L, Van Hout Cristopher V, Shuldiner Alan R, Bogardus Clifton, Baier Leslie J
Abstract excerpt
Insulin-like growth factor binding protein 4 (IGFBP4) is involved in adipogenesis, and IGFBP4 null mice have decreased body fat through decreased PPAR-γ expression. In the current study, we assessed whether variation in the IGFBP4 coding region influences body mass index (BMI) in American Indians who are disproportionately affected by obesity. Whole exome sequence data from a population-based sample of 6779...
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