Weighted burden analysis in 200,000 exome-sequenced subjects characterises rare variant effects on BMI.

Abstract excerpt

INTRODUCTION: A number of genes have been identified in which rare variants can cause obesity. Here we analyse a sample of exome sequenced subjects from UK Biobank using BMI as a phenotype with the aims of identifying genes in which rare, functional variants influence BMI and characterising the effects of different categories of variant. METHODS: There were 199,807 exome sequenced subjects for whom BMI was...

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