Article
Exome Sequencing Identifies A Nonsense Variant in DAO Associated With Reduced Energy Expenditure in American Indians.
The Journal of clinical endocrinology and metabolism - 1 Nov 2020
Piaggi Paolo, Köroğlu Çiğdem, Nair Anup K, Sutherland Jeff, Muller Yunhua L, Kumar Pankaj, Hsueh Wen-Chi, Kobes Sayuko, Shuldiner Alan R, Kim Hye In, Gosalia Nehal, Van Hout Cristopher V, Jones Marcus, Knowler William C, Krakoff Jonathan, Hanson Robert L, Bogardus Clifton, Baier Leslie J
Abstract excerpt
BACKGROUND: Obesity and energy expenditure (EE) are heritable and genetic variants influencing EE may contribute to the development of obesity. We sought to identify genetic variants that affect EE in American Indians, an ethnic group with high prevalence of obesity. METHODS: Whole-exome sequencing was performed in 373 healthy Pima Indians informative for 24-hour EE during energy balance. Genetic association...
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