Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.

Obesity (Silver Spring, Md.) - 1 Apr 2014

Huang Ke, Nair Anup K, Muller Yunhua Li, Piaggi Paolo, Bian Li, Del Rosario Melissa, Knowler William C, Kobes Sayuko, Hanson Robert L, Bogardus Clifton, Baier Leslie J

Abstract excerpt

OBJECTIVE: Few coding variants in genes associated with type 2 diabetes (T2D) have been identified, and the underlying physiologic mechanisms whereby susceptibility genes influence T2D risk are often unknown. The objective of this study was to identify coding variation that increases risk for T2D via an effect on a pre-diabetic trait. METHODS: Whole exome sequencing was done in 177 Pima Indians. Selected variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to Cytochromes b5

Share to Diabetes Mellitus, Type 2

Share to Indians, North American

Share to Insulin

Source

Open in PubMed Open full text

Identifiers

PMID: 24151200
DOI: 10.1002/oby.20647
PMCID: PMC3968243

Genes

RNF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.PMID 24151200Read ↗

Exome Chip Analysis of 14,026 Koreans Reveals Known and Newly Discovered Genetic Loci Associated with Type 2 Diabetes Mellitus.Semantic proximity Read ↗

Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank.Semantic proximity Read ↗

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.Semantic proximity Read ↗

Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity.Semantic proximity Read ↗

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.Semantic proximity Read ↗

Weighted burden analysis in 200,000 exome-sequenced subjects characterises rare variant effects on risk of type 2 diabetesSemantic proximity Read ↗

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestriesSemantic proximity Read ↗

Analysis of rare coding variants in 470,000 exome-sequenced subjects characterises contributions to risk of type 2 diabetesSemantic proximity Read ↗

An ancestry-enriched HNF4A variant and GP2 reveal distinct mechanisms of type 2 diabetes in exome-wide study of 13,674 cases and 41,024 controlsSemantic proximity Read ↗

Analysis of rare coding variants in 200,000 exome-sequenced subjects reveals novel genetic risk factors for type 2 diabetes.Semantic proximity Read ↗

Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits.Semantic proximity Read ↗

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.