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Article

Pleiotropic Effects of an eQTL in the CELSR2/PSRC1/SORT1 Cluster That Associates With LDL-C and Resting Metabolic Rate.

The Journal of clinical endocrinology and metabolism - 21 Jan 2025

Bandesh Khushdeep, Freeland Kendrick, Traurig Michael, Hanson Robert L, Bogardus Clifton, Piaggi Paolo, Baier Leslie J

Abstract excerpt

CONTEXT: The locus CELSR2-PSRC1-SORT1, a primary genetic signal for lipids, has recently been implicated in different metabolic processes. Our investigation identified its association with energy metabolism. OBJECTIVE: This work aimed to determine biological mechanisms that govern diverse functions of this locus. METHODS: Genotypes for 491 265 variants in 7000 clinically characterized American Indians were...

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Source

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Identifiers

PMID: 39018443
DOI: 10.1210/clinem/dgae498
PMCID: PMC11747693

Genes

CELSR2
PSRC1
SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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