Article
Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells.
Diabetes - 1 Apr 2022
Carrasco Manuel, Wang Chencheng, Søviknes Anne M, Bjørlykke Yngvild, Abadpour Shadab, Paulo Joao A, Tjora Erling, Njølstad Pål, Ghabayen Jonas, Nermoen Ingrid, Lyssenko Valeriya, Chera Simona, Ghila Luiza M, Vaudel Marc, Scholz Hanne, Ræder Helge
Abstract excerpt
Studies of monogenic diabetes are particularly useful because we can gain insight into the molecular events of pancreatic β-cell failure. Maturity-onset diabetes of the young 1 (MODY1) is a form of monogenic diabetes caused by a mutation in the HNF4A gene. Human-induced pluripotent stem cells (hiPSCs) provide an excellent tool for disease modeling by subsequently directing differentiation toward desired...
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