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Article

Rethinking HNF1A-MODY: HNF1A at the crossroads of development and multiorgan metabolic disease.

Genes & development - 1 Jun 2026

Warin Julie, Grapin-Botton Anne

Abstract excerpt

In this issue of Genes & Development, Unger and colleagues (doi:10.1101/gad.353153.125) combined human pluripotent stem cell-derived in vitro models with targeted in vivo mouse models to reveal multiple developmental defects triggered by HNF1A mutations causing maturity-onset diabetes of the young. This work paints the picture of a disorder that starts well before diabetes manifests, highlighting its complexity...

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Identifiers

PMID: 42020312
DOI: 10.1101/gad.353709.126
PMCID: PMC13224850

Genes

HNF1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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