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Integrated transcriptome and proteome analyses unveil cytoskeletal alterations in an endothelial model of monogenic diabetes.

Genome medicine - 27 Feb 2026

Skoczek Dawid, Kloska Damian, Targosz-Korecka Marta, Szade Krzysztof, Biela Artur, Hohendorff Jerzy, Babincak Marian, Kopacz Aleksandra, Malecki Maciej T, Stepniewski Jacek, Kachamakova-Trojanowska Neli

Abstract excerpt

BACKGROUND: HNF1A-MODY is a subtype of monogenic diabetes caused by mutations in the hepatocyte nuclear factor-1 homeobox A (HNF1A) gene. While the role of HNF1A in pancreatic beta cells has been extensively studied, its role in other cell types, such as endothelial cells (ECs), is less understood. Despite the pharmacologically controlled glycemia in HNF1A-MODY patients, still cardiovascular disorders and other...

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Identifiers

PMID: 41749365
DOI: 10.1186/s13073-026-01615-z
PMCID: PMC13049728

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HNF1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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