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Article

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis.

Brain : a journal of neurology - 18 Apr 2022

Taha Doaa M, Clarke Benjamin E, Hall Claire E, Tyzack Giulia E, Ziff Oliver J, Greensmith Linda, Kalmar Bernadett, Ahmed Mhoriam, Alam Aftab, Thelin Eric P, Garcia Nuria Marco, Helmy Adel, Sibley Christopher R, Patani Rickie

Abstract excerpt

Amyotrophic lateral sclerosis is a rapidly progressive and fatal disease. Although astrocytes are increasingly recognized contributors to the underlying pathogenesis, the cellular autonomy and uniformity of astrocyte reactive transformation in different genetic forms of amyotrophic lateral sclerosis remain unresolved. Here we systematically examine these issues by using highly enriched and human induced...

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Identifiers

PMID: 35042241
DOI: 10.1093/brain/awab328
PMCID: PMC9014746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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