Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reactive astrocytes in ALS display diminished intron retention.

Nucleic acids research - 6 Apr 2021

Ziff Oliver J, Taha Doaa M, Crerar Hamish, Clarke Benjamin E, Chakrabarti Anob M, Kelly Gavin, Neeves Jacob, Tyzack Giulia E, Luscombe Nicholas M, Patani Rickie

Abstract excerpt

Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human-induced pluripotent stem cell (hiPSC)-derived astrocytes carrying ALS-causing mutations in VCP, SOD1 and C9orf72. Notably, transcripts with decreased IR and increased expression are overrepresented in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Astrocytes

Share to Calcium Channels

Share to Cytoplasm

Share to Superoxide Dismutase-1

Share to Translocation, Genetic

Share to Valosin Containing Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 33684213
DOI: 10.1093/nar/gkab115
PMCID: PMC8034657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reactive astrocytes in ALS display diminished intron retention.PMID 33684213Read ↗

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states.Semantic proximity Read ↗

An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalizationSemantic proximity Read ↗

Post-transcriptional remodelling is temporally deregulated during motor neurogenesis in human ALS modelsSemantic proximity Read ↗

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis.Semantic proximity Read ↗

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Single-nucleus multiomic atlas of ALS primary motor cortex nominates neuroprotective WDR49-expressing astrocytesSemantic proximity Read ↗

Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expressionSemantic proximity Read ↗

Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress.Semantic proximity Read ↗

Transcriptomic profiling uncovers mis-splicing and gene fusions in amyotrophic lateral sclerosisSemantic proximity Read ↗

Intercellular Transfer of PTBP1 Drives Human Neural Stem Cell FateSemantic proximity Read ↗

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALSSemantic proximity Read ↗

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.