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Article

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with <i>SOD1</i> mutations

2023-10-07

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by the progressive death of motor neurons (MNs). MN degeneration in ALS involves both cell-autonomous and non-cell autonomous mechanisms, with glial cells playing important roles in the latter. More specifically, astrocytes with mutations in the ALS-associated gene Cu/Zn superoxide dismutase 1 ( SOD1 ) promote MN death. The mechanis...

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Literature Corpus work
22420826-909d-50bf-b365-44cb1dcf7e5d
DOI
10.1101/2023.10.05.561079
Open publication

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Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with <i>SOD1</i> mutationsDOI 10.1101/2023.10.05.561079
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