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Article

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2011

Díaz-Amarilla Pablo, Olivera-Bravo Silvia, Trias Emiliano, Cragnolini Andrea, Martínez-Palma Laura, Cassina Patricia, Beckman Joseph, Barbeito Luis

Abstract excerpt

Motoneuron loss and reactive astrocytosis are pathological hallmarks of amyotrophic lateral sclerosis (ALS), a paralytic neurodegenerative disease that can be triggered by mutations in Cu-Zn superoxide dismutase (SOD1). Dysfunctional astrocytes contribute to ALS pathogenesis, inducing motoneuron damage and accelerating disease progression. However, it is unknown whether ALS progression is associated with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22010221
DOI: 10.1073/pnas.1110689108
PMCID: PMC3207668

Genes

SOD1

Variants

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