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An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor

22 Mar 2016

Abstract excerpt

Human Aurora kinases, including Aurora kinase A (AURKA), B (AURKB), and C (AURKC), play an essential role in mitotic events such as monitoring of the mitotic checkpoint, creation of bipolar mitotic spindle and alignment of centrosomes on it, also regulating centrosome separation, bio-orientation of chromosomes and cytokinesis. AURKA and AURKB are key regulators of mitosis and centrosome via polymerizing...

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PMID: 26999067
DOI: 10.1111/1440-1681.12571

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