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Article

High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity.

Frontiers in immunology - 1 Jan 2021

Amorim Leonardo M, Augusto Danillo G, Nemat-Gorgani Neda, Montero-Martin Gonzalo, Marin Wesley M, Shams Hengameh, Dandekar Ravi, Caillier Stacy, Parham Peter, Fernández-Viña Marcelo A, Oksenberg Jorge R, Norman Paul J, Hollenbach Jill A

Abstract excerpt

The KIR (killer-cell immunoglobulin-like receptor) region is characterized by structural variation and high sequence similarity among genes, imposing technical difficulties for analysis. We undertook the most comprehensive study to date of KIR genetic diversity in a large population sample, applying next-generation sequencing in 2,130 United States European-descendant individuals. Data were analyzed using our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34025673
DOI: 10.3389/fimmu.2021.674778
PMCID: PMC8137979

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