Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inherited predisposition to malignant mesothelioma: germline BAP1 mutations and beyond.

European review for medical and pharmacological sciences - 1 Jun 2021

Pagliuca F, Zito Marino F, Morgillo F, Della Corte C, Santini M, Vicidomini G, Guggino G, De Dominicis G, Campione S, Accardo M, Cozzolino I, Franco R

Abstract excerpt

Malignant mesothelioma (MM) is a rare aggressive neoplasm arising from mesothelial lining of body cavities, most commonly pleura and peritoneum. It is characterised by a poor prognosis and limited treatment options. A universally recognised risk factor for the development of MM is exposure to asbestos. However, evidence supporting a genetic susceptibility to the development of MM has been accumulating during the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Mesothelioma, Malignant

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

Source

Identifiers

PMID: 34227091
DOI: 10.26355/eurrev_202106_26129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inherited predisposition to malignant mesothelioma: germline BAP1 mutations and beyond.PMID 34227091Read ↗

Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer.Semantic proximity Read ↗

Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genesSemantic proximity Read ↗

BAP1 Mutations and Pleural Mesothelioma: Genetic Insights, Clinical Implications, and Therapeutic PerspectivesSemantic proximity Read ↗

A Subset of Mesotheliomas With Improved Survival Occurring in Carriers ofBAP1and Other Germline MutationsSemantic proximity Read ↗

BAP1, a tumor suppressor gene driving malignant mesotheliomaSemantic proximity Read ↗

Germline BAP1 mutations predispose to malignant mesothelioma.Semantic proximity Read ↗

Mesothelioma families without inheritance of a BAP1 predisposing mutation.Semantic proximity Read ↗

Clinical and Pathologic Phenotyping of Mesotheliomas Developing in Carriers of Germline BAP1 Mutations.Semantic proximity Read ↗

Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review.Semantic proximity Read ↗

Detecting germline BAP1 mutations in patients with peritoneal mesothelioma: benefits to patient and family membersSemantic proximity Read ↗

The Importance of Multidisciplinary Approach in Early Detection of BAP1 Tumor Predisposition Syndrome: Clinical Management and Risk AssessmentSemantic proximity Read ↗

Prospective Analysis of Mesotheliomas in Subjects With BAP1 Cancer Syndrome: Clinical Characteristics and Epigenetic Correlates of DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.