Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.

doi:10.1200/JCO.2018.78.5204

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Oct 2018

Panou Vasiliki, Gadiraju Meghana, Wolin Arthur, Weipert Caroline M, Skarda Emily, Husain Aliya N, Patel Jyoti D, Rose Buerkley, Zhang Shannon R, Weatherly Madison, Nelakuditi Viswateja, Knight Johnson Amy, Helgeson Maria, Fischer David, Desai Arpita, Sulai Nanna, Ritterhouse Lauren, Røe Oluf D, Turaga Kiran K, Huo Dezheng, Segal Jeremy, Kadri Sabah, Li Zejuan, Kindler Hedy L, Churpek Jane E

Abstract excerpt

PURPOSE: The aim of the current study was to determine the prevalence and clinical predictors of germline cancer susceptibility mutations in patients with malignant mesothelioma (MM). METHODS: We performed targeted capture and next-generation sequencing of 85 cancer susceptibility genes on germline DNA from 198 patients with pleural, peritoneal, and tunica vaginalis MM. RESULTS: Twenty-four germline mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Germ-Line Mutation

Share to High-Throughput Nucleotide Sequencing

Share to Lung Neoplasms

Share to Mesothelioma

Share to Mesothelioma, Malignant

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 30113886
DOI: 10.1200/JCO.2018.78.5204
PMCID: PMC6804864

Genes

BAP1
BRCA2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.PMID 30113886Read ↗

Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas.Semantic proximity Read ↗

New pathogenic germline variants identified in mesothelioma.Semantic proximity Read ↗

A Subset of Mesotheliomas With Improved Survival Occurring in Carriers ofBAP1and Other Germline MutationsSemantic proximity Read ↗

Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival.Semantic proximity Read ↗

Inherited predisposition to malignant mesothelioma: germline BAP1 mutations and beyond.Semantic proximity Read ↗

Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review.Semantic proximity Read ↗

Novel LRRK2 mutations and other rare, non-BAP1-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other tumors.Semantic proximity Read ↗

BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma.Semantic proximity Read ↗

Malignant pleural mesothelioma: Germline variants in DNA repair genes may steer tailored treatmentSemantic proximity Read ↗

Prevalence of incidental germline variants detected via tumor-only mesothelioma genomic profilingSemantic proximity Read ↗

Clinical and Pathologic Phenotyping of Mesotheliomas Developing in Carriers of Germline BAP1 Mutations.Semantic proximity Read ↗

Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.