Article
Germline mutations in DNA repair genes predispose asbestos-exposed patients to malignant pleural mesothelioma.
Cancer letters - 1 Oct 2017
Betti Marta, Casalone Elisabetta, Ferrante Daniela, Aspesi Anna, Morleo Giulia, Biasi Alessandra, Sculco Marika, Mancuso Giuseppe, Guarrera Simonetta, Righi Luisella, Grosso Federica, Libener Roberta, Pavesi Mansueto, Mariani Narciso, Casadio Caterina, Boldorini Renzo, Mirabelli Dario, Pasini Barbara, Magnani Corrado, Matullo Giuseppe, Dianzani Irma
Abstract excerpt
Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer caused by asbestos exposure. An inherited predisposition has been suggested to explain multiple cases in the same family and the observation that not all individuals highly exposed to asbestos develop the tumor. Germline mutations in BAP1 are responsible for a rare cancer predisposition syndrome that includes predisposition to mesothelioma. We...
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