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Article

Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2020

Guo Robin, DuBoff Mariel, Jayakumaran Gowtham, Kris Mark G, Ladanyi Marc, Robson Mark E, Mandelker Diana, Zauderer Marjorie G

Abstract excerpt

INTRODUCTION: Although next-generation sequencing (NGS) has brought insight into critical mutations or pathways (e.g., DNA damage sensing and repair) involved in the etiology of many cancers and has directed new screening, prevention, and therapeutic approaches for patients and families, it has only recently been used in malignant pleural mesotheliomas (MPMs). METHODS: We analyzed the blood samples from patients...

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Identifiers

PMID: 31887429
DOI: 10.1016/j.jtho.2019.12.111
PMCID: PMC7526793

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