Article
Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads.
Human molecular genetics - 1 Dec 2015
Auguste Aurélie, Bessière Laurianne, Todeschini Anne-Laure, Caburet Sandrine, Sarnacki Sabine, Prat Jaime, D'angelo Emanuela, De La Grange Pierre, Ariste Olivier, Lemoine Fréderic, Legois Bérangère, Sultan Charles, Zider Alain, Galmiche Louise, Kalfa Nicolas, Veitia Reiner A
Abstract excerpt
Juvenile granulosa cell tumors (JGCTs) of the ovary are pediatric neoplasms representing 5% of all granulosa cell tumors (GCTs). Most GCTs are of adult type (AGCTs) and bear a mutation in the FOXL2 gene. The molecular basis of JGCTs is poorly understood, although mutations in the GNAS gene have been reported. We have detected in-frame duplications within the oncogene AKT1 in >60% of the JGCTs studied. Here, to...
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