Article
KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary.
Nature communications - 27 Jun 2018
Hillman R Tyler, Celestino Joseph, Terranova Christopher, Beird Hannah C, Gumbs Curtis, Little Latasha, Nguyen Tri, Thornton Rebecca, Tippen Samantha, Zhang Jianhua, Lu Karen H, Gershenson David M, Rai Kunal, Broaddus Russell R, Futreal P Andrew
Abstract excerpt
Adult-type granulosa cell tumors of the ovary (aGCTs) are rare gynecologic malignancies that exhibit a high frequency of somatic FOXL2 c.C402G (p.Cys134Trp) mutation. Treatment of relapsed aGCT remains a significant clinical challenge. Here we show, using whole-exome and cancer gene panel sequencing of 79 aGCTs from two independent cohorts, that truncating mutation of the histone lysine methyltransferase gene...
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