Article
Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis.
JCI insight - 22 Feb 2022
Sasaki Kensuke, Terker Andrew S, Tang Jiaqi, Cao Shirong, Arroyo Juan Pablo, Niu Aolei, Wang Suwan, Fan Xiaofeng, Zhang Yahua, Bennett Stephanie R, Zhang Ming-Zhi, Harris Raymond C
Abstract excerpt
Aristolochic acid (AA) is the causative nephrotoxic alkaloid in AA nephropathy, which results in a tubulointerstitial fibrosis. AA causes direct proximal tubule damage as well as an influx of macrophages, although the role of macrophages in pathogenesis is poorly understood. Here, we demonstrate that AA directly stimulates migration, inflammation, and ROS production in macrophages ex vivo. Cells lacking...
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