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Article

Pharmacological targeting macrophage phenotype via gut-kidney axis ameliorates renal fibrosis in mice.

Pharmacological research - 1 Apr 2022

Xie Yanan, Hu Xiaofan, Li Shanglin, Qiu Yang, Cao Rui, Xu Cong, Lu Chenqi, Wang Zhimin, Yang Jun

Abstract excerpt

Renal fibrosis is a non-negligible pathological change in chronic kidney disease (CKD). Increasing evidence indicates that macrophage and gut-kidney axis are correlated with CKD. In this study, we manifest that pharmacological modulating macrophage phenotype via gut-kidney axis is conducive to the alleviation of renal fibrosis. Employing wild-type male mice with unilateral ureteral obstruction (UUO), renal...

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PMID: 35259481
DOI: 10.1016/j.phrs.2022.106161

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