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Article

Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats.

American journal of physiology. Renal physiology - 15 Mar 2013

Chen Jun-Feng, Ni Hai-Feng, Pan Ming-Ming, Liu Hong, Xu Min, Zhang Ming-Hui, Liu Bi-Cheng

Abstract excerpt

Tubulointerstitial macrophage infiltration is a hallmark of chronic kidney disease involved in the progression of renal fibrosis. Pirfenidone is a newly identified antifibrotic drug, the potential mechanism of which remains unclear. The aim of this study was to investigate the effects of pirfenidone on M1/M2 macrophage infiltration in nephrectomized rats. Nephrectomized rats were treated with pirfenidone by...

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Source

Identifiers

PMID: 23152296
DOI: 10.1152/ajprenal.00507.2012

Genes

MIP
CCR7
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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