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Article

Macrophage Migration Inhibitory Factor Limits Renal Inflammation and Fibrosis by Counteracting Tubular Cell Cycle Arrest.

Journal of the American Society of Nephrology : JASN - 1 Dec 2017

Djudjaj Sonja, Martin Ina V, Buhl Eva M, Nothofer Nina J, Leng Lin, Piecychna Marta, Floege Jürgen, Bernhagen Jürgen, Bucala Richard, Boor Peter

Abstract excerpt

Renal fibrosis is a common underlying process of progressive kidney diseases. We investigated the role of macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, in this process. In mice subjected to unilateral ureteral obstruction, genetic deletion or pharmacologic inhibition of MIF aggravated fibrosis and inflammation, whereas treatment with recombinant MIF was beneficial, even in...

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Identifiers

PMID: 28801314
DOI: 10.1681/ASN.2017020190
PMCID: PMC5698074

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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