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A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins

14 Feb 2022

Abstract excerpt

BACKGROUND: The gasdermins (GSDMs) family is proposed to be pore-forming effector proteins that cause cell membrane permeabilization and pyroptosis. Despite our increasing knowledge of GSDMD, GSDME and GSDMB, the biological functions and the regulation of GSDM expression and activation remain elusive for most GSDMs. In this study, we analyzed the molecular characteristics and oncogenic role of GSDM family genes...

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PMID: 35164740
DOI: 10.1186/s12935-022-02483-4

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