Article

Dsg2 truncation causes a lethal barrier breakdown in mice

2024-07-03

Abstract excerpt

Inflammatory bowel diseases (IBD) such as Crohn’s disease (CD) have a complex aetiology with alterations of both the intestinal epithelial barrier and the IL23/IL17 immune response. Here, we investigated the role of a novel mutation in the desmosomal cadherin desmoglein 2 gene ( DSG2 ) in the pathogenesis of IBD. DSG2 is known to regulate intestinal epithelial barrier integrity. Genetic analysis of a CD patient r...

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Literature Corpus work: 65d3e559-f761-5511-b381-c482413e30c2
DOI: 10.1101/2024.07.01.601522

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