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Article

DNA variants affecting chromatin structure are key to the genetic architecture of obsessive compulsive disorder.

Epigenetics & chromatin - 19 Jan 2026

Han Velda X, Patel Shrujna, Mohammad Shekeeb S, Dale Russell C

Abstract excerpt

BACKGROUND: Obsessive Compulsive Disorder (OCD) affects 2 to 3% of the population and is marked by intrusive thoughts and repetitive behaviours. OCD is increasingly recognized as a polygenic disorder involving gene-environment interactions, with genetic risk largely driven by common variants and a smaller contribution from rare pathogenic variation. Despite these insights, the functional roles of implicated genes...

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Identifiers

PMID: 41555428
DOI: 10.1186/s13072-025-00643-0
PMCID: PMC12817438

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