Article
Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model.
Investigational new drugs - 1 Jun 2022
Alves-Silva Antônio Bruno, Fenerich Bruna Alves, Fonseca Natasha Peixoto, Fernandes Jaqueline Cristina, Coelho-Silva Juan Luiz, Pereira-Martins Diego Antonio, Bianco Thiago Mantello, Scheucher Priscila Santos, Rego Eduardo Magalhães, Chahud Fernando, Machado-Neto João Agostinho, Figueiredo-Pontes Lorena Lôbo, Traina Fabiola
Abstract excerpt
BACKGROUND: Myeloproliferative neoplasms (MPN) are disorders characterized by an alteration at the hematopoietic stem cell (HSC) level, where the JAK2 mutation is the most common genetic alteration found in classic MPN (polycythemia vera, essential thrombocythemia, and primary myelofibrosis). We and others previously demonstrated that metformin reduced splenomegaly and platelets counts in peripheral blood in...
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