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Article

Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway.

Molecular nutrition & food research - 1 Nov 2015

Trung Ly Quoc, Espinoza J Luis, An Dao T, Viet Nguyen Hoang, Shimoda Kazuya, Nakao Shinji

Abstract excerpt

SCOPE: Resveratrol is a natural occurring polyphenol with several health promoting activities, including anticancer potential. Here, we analyzed the cytotoxic effects of resveratrol against malignant cells characterized by aberrant activation of the Janus kinase 2 (JAK2). METHODS AND RESULTS: Cell-cycle analysis, proliferation, apoptosis, and Western blotting assays were performed to study the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26375873
DOI: 10.1002/mnfr.201500166

Genes

JAK2
JAK1
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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