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Article

The glutaminase inhibitor CB-839 targets metabolic dependencies of JAK2-mutant hematopoiesis in MPN.

Blood advances - 14 May 2024

Usart Marc, Hansen Nils, Stetka Jan, Almeida Fonseca Tiago, Guy Alexandre, Kimmerlin Quentin, Rai Shivam, Hao-Shen Hui, Roux Julien, Dirnhofer Stefan, Skoda Radek C

Abstract excerpt

ABSTRACT: Hyperproliferation of myeloid and erythroid cells in myeloproliferative neoplasms (MPN) driven by the JAK2-V617F mutation is associated with altered metabolism. Given the central role of glutamine in anabolic and catabolic pathways, we examined the effects of pharmacologically inhibiting glutaminolysis, that is, the conversion of glutamine (Gln) to glutamate (Glu), using CB-839, a small molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38295283
DOI: 10.1182/bloodadvances.2023010950
PMCID: PMC11117009

Genes

JAK2
GLS
CD34
JAK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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