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Article

Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.

The Journal of clinical investigation - 1 Feb 2024

He Fan, Laranjeira Angelo Ba, Kong Tim, Lin Shuyang, Ashworth Katrina J, Liu Alice, Lasky Nina M, Fisher Daniel Ac, Cox Maggie J, Fulbright Mary C, Antunes-Heck Lilian, Yu LaYow, Brakhane Molly, Gao Bei, Sykes Stephen M, D'Alessandro Angelo, Di Paola Jorge, Oh Stephen T

Abstract excerpt

Platelets from patients with myeloproliferative neoplasms (MPNs) exhibit a hyperreactive phenotype. Here, we found elevated P-selectin exposure and platelet-leukocyte aggregates indicating activation of platelets from essential thrombocythemia (ET) patients. Single-cell RNA-seq analysis of primary samples revealed significant enrichment of transcripts related to platelet activation, mTOR, and oxidative...

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Identifiers

PMID: 38060311
DOI: 10.1172/JCI172256
PMCID: PMC10836808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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