Article

Potential Utility of PPARγ Agonists in the Eradication of Chronic Myeloid Leukemia Stem Cells

2025-08-06

Abstract excerpt

<title>Abstract</title> <p> Tyrosine kinase inhibitors (TKIs) have transformed the treatment of chronic myeloid leukemia (CML), yet persistent leukemia stem cells (LSCs) remain a barrier to cure. PPARγ agonists like pioglitazone have been proposed to enhance eradication of LSCs when used alongside TKIs. This study investigated the impact of adding pioglitazone to imatinib therapy in 26 newly diagnosed chronic-ph...

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Literature Corpus work: edadc08d-6541-555c-9c83-f30fe3914ac6
DOI: 10.21203/rs.3.rs-7140724/v1

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