Article

Long-term combination therapy with Metformin and Oxymetholone in a Fanconi Anemia mouse model

2023-08-16

Abstract excerpt

Fanconi Anemia (FA) is a disease caused by defective DNA repair which manifests as bone marrow failure, cancer predisposition, and developmental defects. Mice containing inactivating mutations in one or more genes in the FA pathway partially mimic the human disease. We previously reported that monotherapy with either metformin (MET) or oxymetholone (OXM) improved peripheral blood (PB) counts and the number and fun...

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Literature Corpus work: 0f08a934-f840-50e9-b910-f3e33afb73f3
DOI: 10.1101/2023.08.16.553572

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