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Article

Epigenetic Regulation of <i>F2RL3</i> Associates With Myocardial Infarction and Platelet Function

11 Jan 2022

Abstract excerpt

Background: DNA hypomethylation at the F2RL3 (F2R like thrombin or trypsin receptor 3) locus has been associated with both smoking and atherosclerotic cardiovascular disease; whether these smoking-related associations form a pathway to disease is unknown. F2RL3 encodes protease-activated receptor 4, a potent thrombin receptor expressed on platelets. Given the role of thrombin in platelet activation and the role...

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PMID: 35012325
DOI: 10.1161/circresaha.121.318836

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