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Article

Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.

Thrombosis and haemostasis - 3 May 2017

Kong Xianguo, Simon Lukas M, Holinstat Michael, Shaw Chad A, Bray Paul F, Edelstein Leonard C

Abstract excerpt

Platelet activation in response to stimulation of the Protease Activated Receptor 4 (PAR4) receptor differs by race. One factor that contributes to this difference is the expression level of Phosphatidylcholine Transfer Protein (PCTP), a regulator of platelet PAR4 function. We have conducted an expression Quantitative Trait Locus (eQTL) analysis that identifies single nucleotide polymorphisms (SNPs) linked to the...

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Source

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Identifiers

PMID: 28251237
DOI: 10.1160/TH16-09-0692
PMCID: PMC5512274

Genes

PCTP
GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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