Article
The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma.
Frontiers in endocrinology - 1 Jan 2023
Wang Yuxiong, Liu Bin, Li Faping, Zhang Yanghe, Gao Xin, Wang Yishu, Zhou Honglan
Abstract excerpt
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors originating from chromaffin cells, holding significant clinical importance due to their capacity for excessive catecholamine secretion and associated cardiovascular complications. Roughly 80% of cases are associated with genetic mutations. Based on the functionality of these mutated genes, PPGLs can be categorized into distinct molecular...
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