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Article

Inducing Energetic Switching Using Klotho Improves Vascular Smooth Muscle Cell Phenotype.

International journal of molecular sciences - 25 Dec 2021

Docherty Craig K, Strembitska Anastasiya, Baker Christa P, Schmidt Fiona F, Reay Kieran, Mercer John R

Abstract excerpt

The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM), and defects in mitochondrial oxidative metabolism as significant observations. The antiageing protein Klotho could prolong VSMC survival in the atherosclerotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Identifiers

PMID: 35008643
DOI: 10.3390/ijms23010217
PMCID: PMC8745077

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