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Article

Novel application of paeoniflorin: Stabilization of atherosclerotic plaques via the AMPK/PPARδ signaling pathway.

Vascular pharmacology - 1 Sept 2026

He Jiqian, Liu Jiali, Zheng Zhensen, Fan Faxin, Luo Zhizhong, Luo Duosheng

Abstract excerpt

BACKGROUND: Phenotypic switching of smooth muscle cells is a core event in atherosclerosis, and atherosclerosis is recognized as a smooth muscle cell-driven tumor-like disease. Paeoniflorin (PF), a bioactive monoterpene glycoside isolated from Paeonia lactiflora and Paeonia veitchii, which exerts beneficial effects on both cardiovascular diseases and tumors. However, whether it ameliorates atherosclerosis by...

Read the complete abstract on PubMed

Topics

Animals
Monoterpenes
Glucosides
Signal Transduction
Atherosclerosis
AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Glycosides

Plaque, Atherosclerotic

Muscle, Smooth, Vascular

Mice, Knockout, ApoE

Male

Myocytes, Smooth Muscle

Cells, Cultured

Disease Models, Animal

Mice, Inbred C57BL

Endoplasmic Reticulum Chaperone BiP

Phenotype

PPAR gamma

Source

Identifiers

PMID: 42603593
DOI: 10.1016/j.vph.2026.107690

Genes

KLF4
MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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